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Hereditary angioedema (HAE) is a rare, genetic disease that can be unpredictable and potentially life-threatening.1-3

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What is HAE?

HAE is a rare disease that affects about 1 in 50,000 people in the entire world. It is characterized by recurrent attacks of angioedema without urticaria or pruritus. HAE attacks cause mild to severe swelling of various areas of the body, including the extremities, face, genitals, gastrointestinal tract, or upper airway.1,3

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How can HAE impact patients?

HAE can impact the personal, social, and professional lives of patients and may hinder their ability to perform basic daily tasks, participate in social or professional events, travel, or even leave the house during HAE attacks.4

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How can HAE be managed?

Coordination and collaboration between all healthcare providers and the patient is important when developing an individualized HAE management plan.5

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  1. Longhurst HJ, Bork K. Hereditary angioedema: causes, manifestations and treatment. Br J Hosp Med (Lond). 2006;67(12):654-657.
  2. Bork K, Meng G, Staubach P, Hardt J. Hereditary angioedema: new findings concerning symptoms, affected organs, and course. Am J Med. 2006;119(3):267-274.
  3. Zuraw BL. Clinical practice. Hereditary angioedema. N Engl J Med. 2008;359(10):1027-1036
  4. Longhurst HJ, Bork K. Hereditary angioedema: an update on causes, manifestations and treatment. Br J Hosp Med (Lond). 2019;80(7):391-398. doi:10.12968/hmed.2019.80.7.391
  5. Busse PJ, Christiansen SC, Riedl MA, et al. US HAEA Medical Advisory Board 2020 guidelines for the management of hereditary angioedema. J Allergy Clin Immunol Pract. 2021;9(1):132-150. doi:10.1016/j.jaip.2020.08.046