Causes

“I learn everything I can about HAE  and how it might affect me.”

Lesa — Diagnosed with HAE in 1980

Discover what causes HAE

Although not all is known about the events that induce angioedema attacks in hereditary angioedema (HAE), studies show that people with HAE either do not have enough of an important protein called C1-esterase inhibitor or it doesn't work the way it should.

Cause of hereditary angioedema

C1-esterase inhibitor deficiency causes the condition

C1-esterase inhibitor is a protein found in the blood. When it's at normal levels and working properly, it helps regulate plasma kallikrein activity by blocking its ability to split proteins apart, which is linked to inflammation in the body. Because people with HAE don't have enough working C1-esterase inhibitor, the body has an overactive kallikrein system with nothing to keep it in check. As a result, kallikrein remains active and is able to split a protein apart, which releases another protein called bradykinin.

Bradykinin overproduction causes the symptoms

Having too much bradykinin allows fluid that is normally contained within the blood vessels to leak into the surrounding tissues. This is thought to cause the swelling experienced during an HAE attack.

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